People use Polypodium leucotomos for sunburn, eczema (atopic dermatitis), scaly, itchy skin (psoriasis), a skin disorder that causes white patches to develop on the skin (vitiligo), and many other conditions, but there is no good scientific evidence to support these uses.
Polypodium leucotomos might have antioxidant effects. Antioxidants might prevent damage caused by excessive sun exposure.
The extract of the fern Polypodium leucotomos (PL, Fernblock) is an oral photoprotectant with strong antioxidative properties. … The antioxidant capacity of PL components increased in a concentration-dependent manner, with ferulic and caffeic acids the most powerful antioxidants
Polypodium leucotomos is a South American species of fern in the family Polypodiaceae. For many years, extracts of this fern have been used for treating a variety of skin conditions,12 including psoriasis,13 atopic dermatitis,14 vitiligo,15 polymorphic light eruption,16 and melasma.
The extract of the fern Polypodium leucotomos (PL, Fernblock) is an oral photoprotectant with strong antioxidative properties. Recent studies to determine its chemical composition have shown 4-hydroxycinnamic acid (p-coumaric), 3 methoxy-4-hydroxycinnamic acid (ferulic), 3,4-dihydroxycinnamic acid (caffeic), 3-methoxy-4-hydroxybenzoic acid (vanillic) and 3-caffeoilquinic acid (chlorogenic) to be among its major phenolic components. No conclusive data are available, however, on the H2O2-scavenging capacity of these compounds, or on their absorption and metabolism following their oral intake. In the present work, their antioxidative capacity was assessed by the luminol/H2O2 assay, their absorption studied using Caco-2 cells to resemble the intestinal barrier, and their metabolism investigated using cultured primary rat hepatocytes. The antioxidant capacity of PL components increased in a concentration-dependent manner, with ferulic and caffeic acids the most powerful antioxidants.
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